Glycosylation yog qhov tseem ceeb ntawm txoj hauv kev biosynthetic-secretory hauv endoplasmic reticulum (ER) thiab Golgi apparatus. Kwv yees li ib nrab ntawm tag nrho cov proteins feem ntau qhia hauv lub xovtooj ntawm qhov kev hloov pauv no, uas suav nrog covalent ntxiv ntawm cov piam thaj moieties rau cov amino acids tshwj xeeb.
protein glycosylation tshwm sim nyob qhov twg?
Glycosylation yog qhov txuas ntawm cov piam thaj molecules rau cov proteins los ntawm kev sib txuas glycosidic. Nws tshwm sim nyob rau hauv ER (Endoplasmic Reticulum) thiab Golgi complex lub cev ntawm tes. Yog li glycosylation ntawm supermolecules tshwm sim hauv Endoplasmic reticulum.
Dab tsi ua rau glycosylation ntawm cov proteins?
Protein glycosylation yog hom kev hloov pauv hloov pauv ntau tshaj plaws (PTM) ntawm cov khoom tawm thiab cov cellular membrane-associated proteins (Spiro, 2002). Nws suav nrog qhov kev sib txuas ntawm ntau hom glycans(tseem hu ua carbohydrates, saccharides, lossis qab zib) rau cov protein.
Puas glycosylation tshwm sim ua ntej lossis tom qab cov protein tau muab tais?
Technically, N-glycosylation pib ua ntej cov protein txawm yog txhais, raws li dolicol pyrophosphate oligosaccharide (piv txwv li qab zib "ntoo" - tsis yog lub ntsiab lus, los ntawm txoj kev.) yog synthesized hauv ER (Daim duab 11.4.
Glycosylation tshwm sim li cas?
Glycosylation yog txheej txheem uas yog carbohydratecovalently txuas mus rau lub hom phiaj macromolecule, feem ntau cov proteins thiab lipids. Qhov kev hloov kho no ua haujlwm rau ntau yam haujlwm. … Hauv lwm qhov xwm txheej, cov proteins tsis ruaj khov tshwj tsis yog lawv muaj oligosaccharides txuas ntawm amide nitrogen ntawm qee yam asparagine residues.
