Cov lus teb ntawm R2 tom qab lidocaine yuav tsis tas yuav xoom vim nws tau sau cov lej ntawm txhua qhov kev ua tau zoo thiab qee qhov axons yuav tsis cuam tshuam. Cov hlab ntsha yog ib pob ntawm axons, thiab qee cov hlab ntsha tsis tshua nkag siab rau lidocaine.
Lidocaine cuam tshuam li cas muaj peev xwm ua tau?
Ntxiv lidocaine yog li ua rau lub cell puas tsimqhov ua haujlwm me me, lossis tiv thaiv cov cell puas los ntawm kev tsim cov peev txheej ntawm txhua qhov.
Lidocaine ua li cas rau qhov hluav taws xob-gated Na+?
Lidocaine, uas tau siv hauv kev kho mob rau ntau tshaj 60 xyoo, yog ib qho ntawm cov tshuaj loog siv hauv zos thiab muaj txiaj ntsig zoo rau kho ventricular arrhythmias. … Lidocaine khi rau qhov hluav taws xob-gated sodium channels hauv 1: 1 zam thiab tiv thaiv kev ntws ntawm sodium ions los ntawm cov channel pore.
Lidocaine ua li cas rau qhov hluav taws xob-gated Na ntxiv cov kev cuam tshuam lidocaine txawv li cas ntawm TTX?
Lidocaine thaiv qhov kev nthuav tawm ntawm Na + los ntawm qhov hluav taws xob-gated Na + channels. Qhov txawv ntawm TTX thiab lidocaine yog tias lidocaine cov nyhuv yog thim rov qab. Qhov voltage-gated Na + raws ntawm qhov kev txhawb nqa thiab R1 tsis cuam tshuam los ntawm TTX.
Puas lidocaine muaj zog dua TTX?
Nyob rau hauv txhua rooj plaub, TTX muaj txiaj ntsig ntau dua los txo V,,, tshaj lidocaine. Cov nyhuv ntawm lidocaine txo V,,, yog paub rauyuav frequency dependent (13). … Cov txiaj ntsig no qhia tau hais tias lidocaine txo qis kev ua haujlwm ntev ntawm txhua zaus thiab tseem tuav tau qhov cuam tshuam ntau zaus ntawm V,,,.
