Abstract. Phosphorylase kinase (PhK) integrates hormonal thiab neuronal signals thiab yog a enzyme tseem ceeb hauv kev tswj glycogen metabolism . PhK yog ib qhov loj tshaj plaws ntawm cov protein kinases thiab yog tsim los ntawm plaub hom subunit, nrog stoichiometry (αβγδ)4 thiab tag nrho MW ntawm 1.3 × 10 6.
phosphorylase b kinase ua dab tsi?
Phosphorylase kinase (PhK) coordinates hormonal thiab neuronal signals los pib qhov tawg ntawm glycogen. Lub enzyme catalyzes lub phosphorylation ntawm inactive glycogen phosphorylase b (GPb), uas ua rau tsim cov active glycogen phosphorylase a.
phosphorylase b yog dab tsi?
Phosphorylase a thiab phosphorylase b txawv los ntawm ib pawg phosphoryl hauv txhua lub subunit. Phosphorylase b hloov mus rau hauv phosphorylase thaum nws yog phosphorylated ntawm ib qho serine residue (serine 14) hauv txhua lub subunit. Kev tswj hwm enzyme phosphorylase kinase catalyzes qhov kev hloov kho covalent.
phosphorylase vs kinase yog dab tsi?
Qhov sib txawv tseem ceeb ntawm lawv yog, Kinase yog ib qho enzyme uas catalyzes hloov ntawm ib pawg phosphate los ntawm ATP molecule mus rau ib qho tshwj xeeb moleculewhereas phosphorylase yog ib qho enzyme uas qhia txog ib tug phosphate pawg mus rau hauv cov organic molecule, tshwj xeeb tshaj yog qabzib.
Cov tsos mob dab tsi yuav ua rau daim siab phosphorylase kinase deficiency ua rau?
Nws tseem hu ua PHKB ntsig txogphosphorylase kinase deficiency. Cov tsos mob zoo ib yam li cov neeg uas muaj GSD-IXa. Cov menyuam yaus uas muaj GSD-IXb tuaj yeem tsim muaj lub siab loj (hepatomegaly), hypoglycemia, txo qis cov leeg nqaij (hypotonia), cov leeg tsis muaj zog, thiab kev loj hlob qeeb uas tuaj yeem ua rau menyuam yaus luv luv.
