Kev hloov pauv tom qab kev txhais lus tshwm sim hauv lub ERthiab suav nrog folding, glycosylation, multimeric protein sib dhos thiab proteolytic cleavage ua rau cov protein kom loj hlob thiab ua kom muaj zog. Lawv tshwm sim sai li sai tau thaum cov peptide loj hlob tuaj hauv ER thiab raug hloov kho enzymes.
Kev hloov pauv protein dab tsi tshwm sim hauv ER?
Tshiab cov tshuaj polypeptides nyob rau hauv daim nyias nyias thiab lumen ntawm ER tau dhau tsib qhov kev hloov pauv thawj zaug ua ntej lawv mus txog lawv qhov chaw kawg:
- Kev tsim cov nyiaj disulfide.
- Nyob zoo ib tsoom phooj ywg.
- Ntxiv thiab ua cov carbohydrates.
- Tshwj xeeb proteolytic cleavages.
Kev hloov pauv tom qab kev txhais lus nyob qhov twg hauv cov hlwb?
PTMs tshwm sim ntawm qhov sib txawv ntawm cov amino acid sab chains lossis peptide linkages, thiab lawv feem ntau sib kho los ntawm kev ua haujlwm enzymatic. Qhov tseeb, nws tau kwv yees tias 5% ntawm cov proteome suav nrog cov enzymes uas ua tau ntau dua 200 hom kev hloov kho tom qab kev txhais lus.
Y Yuav hloov pauv cov protein nyob rau hauv protein synthesis yog dab tsi?
Kev hloov pauv hloov pauv tom qab (PTM) yog kev hloov pauv biochemical uas tshwm sim rau ib lossis ntau dua cov amino acids ntawm cov proteintom qab cov protein tau raug txhais los ntawm ribosome.
Dab tsi organelle ua tom qab kev hloov pauv hloov pauv tshwm sim hauv lub cell?
Golgi apparatus ua haujlwm liib txoj kab sib dhos molecular nyob rau hauv uas membrane proteins undergoed post-translational hloov kho. Ntau qhov kev tawm tsam Golgi koom nrog kev sib ntxiv ntawm cov piam thaj residues rau cov kua nplaum membrane thiab cov proteins zais cia.
