Hauv enzymology, penicillin amidase yog ib qho enzyme uas catalyzes cov tshuaj tiv thaiv penicillin + H₂O \rightleftharpoons carboxylate + 6-aminopenicillanate Yog li, ob lub substrates ntawm no enzyme yog penicillin thiab H₂O, whereas nws ob yam khoom thiab carboxy 6-aminopenicillanate.
Penicillin acylase ua dab tsi?
Penicillin acylase (PA, EC 3.5. … Hauv kev xyaum, cov enzyme no feem ntau siv rau produce 6-aminopenicillanic acid, uas yog lub ntsiab synthon hauv kev sib txuas ntawm cov tshuaj tua kab mob penicillin.. PA kuj yog siv rau kev sib txuas ntawm ntau yam semi-synthetic β-lactam tshuaj tua kab mob.
Penicillin amidase tuaj qhov twg?
Ob qhov kev sib cais thiab kev sib txuas lus tuaj yeem ua rau cov tshuaj penicillin amidase. Cov enzyme feem ntau tau txais los ntawm E. coli. Nws yog ib qho heterodimeric periplasmic protein uas muaj ib qho me me ntawm 23 kD thiab loj b-subunit ntawm 62 kD.
Acylases yog dab tsi?
: ib yam ntawm ntau cov enzymes uas hydrolyze acylated amino acids.
Puas yog penicillin ib qho enzyme?
Penicillin acylase yog qhov tshuaj ntsuam enzyme tshaj plaws. Nws tau siv ntau xyoo rau kev tsim cov 6APA [(+)-6-aminopenicillanic acid]. Nws kuj tseem tuaj yeem ua rau muaj ntau yam kev cuam tshuam ntawm cov organic synthesis los tsim lwm cov khoom muaj txiaj ntsig bioactive.
