PD-L1 tau qhia ntau yam ntawm ib txwm thiab lub cev tiv thaiv kab mobthiab muaj ntau dua tam sim no dua li PD-L2 [3]. Cov qog hlwb kuj tau txais qhov PD-1 / PD-L1 cov txheej txheem no txhawm rau txhawm rau tiv thaiv kev tiv thaiv kab mob thiab ua kom cov qog loj hlob [2].
Puas PD-L1 ntawm cov hlwb li qub?
PD-L1 tej zaum yuav pom ntawm qee lub hlwb ib txwmthiab nyob rau hauv cov nyiaj ntau dua li qub ntawm qee hom qog nqaij hlav. Thaum PD-L1 khi rau lwm cov protein hu ua PD-1 (ib qho protein uas pom ntawm T cells), nws ua rau T hlwb tsis txhob tua cov hlwb PD-L1, suav nrog cov qog nqaij hlav cancer.
PD-L1 ib txwm qhia nyob qhov twg?
PD-L1, tseem hu ua CD274 thiab B7-H1, yog ib qho transmembrane protein feem ntau qhia rau saum npoo ntawm antigen nthuav tawm cov hlwb thiab qog hlwb. PD-L1 tshwj xeeb khi rau nws cov receptor, PD-1, uas tau nthuav tawm ntawm qhov chaw ntawm lub cev tiv thaiv kab mob qog noj ntshav, xws li T hlwb, B hlwb, thiab cov hlwb myeloid (11, 12.).
Pob lub cev tiv thaiv kab mob qhia PD-L1?
PD-L1 yog tsim tawm hauv qee cov qog thiab lub cev tiv thaiv kab mob, thiab nws cov lus qhia tuaj yeem raug ntxias lossis tswj hwm los ntawm ntau yam.
Puas PD-1 qhia rau txhua lub T hlwb?
PD-1 yog nthuav tawm ntawm lub xovtooj ntawm tes ntawm lub tshuab ua haujlwm T cells, NK hlwb, B hlwb, macrophages thiab ob peb subsets ntawm DCs.
