Tus neeg ua si tseem ceeb hauv cov txheej txheem catalytic hauv cov serine proteases yog catalytic triad catalytic triad A catalytic triad yog ib pawg ntawm peb pawg amino acidsuas tuaj yeem pom hauv cov nquag qhov chaw ntawm qee cov enzymes. Catalytic triads feem ntau pom muaj nyob rau hauv hydrolase thiab transferase enzymes (xws li proteases, amidases, esterases, acylases, lipases thiab β-lactamases). https://en.wikipedia.org › wiki › Catalytic_triad
Catalytic triad - Wikipedia
. … Cov serine muaj ib pawg -OH uas muaj peev xwm ua tau raws li ib tug nucleophile, tawm tsam cov carbonyl carbon ntawm scissile peptide daim ntawv cog lus ntawm substrate.
Yuav ua li cas serine protease inhibitors ua haujlwm?
Serine protease inhibitors, lossis serpins, suav nrog tsev neeg cov proteins uas antagonize cov haujlwm ntawm serine proteases. … Hauv qhov txheej txheem no, tus serpin nthuav tawm lub substrate-mimicking peptide sib lawv liag-lub reactive center voj-rau nws lub hom phiaj serine protease.
Lub luag haujlwm dab tsi hauv cov tshuaj tiv thaiv serine protease yog ua los ntawm cov nqi xa hluav taws xob?
Lub luag haujlwm ntawm Asp102 hauv catalytic relay system ntawm serine proteases yog kawm theoretically los ntawm xam cov hluav taws xob dawb ntawm ib leeg proton-hloov cov tshuaj tiv thaiv los ntawm Asn102 mutant trypsin thiab cov concerted ob proton-hloov cov tshuaj tiv thaiv (hu ua tus nqi-relay mechanism) ntawm cov tsiaj qus-hom trypsin.
Qhov twg hauv qab no yog piv txwv ntawm serine protease?
Chymotrypsin: >Siv ua piv txwv ntawm serine protease vim nws cov qauv thiab cov txheej txheem tau nkag siab zoo.
yog vim li cas thiaj hu ua serine proteases?
Lawv hu ua serine proteases rau ob qho laj thawj:
- Lawv hydrolyze proteins.
- Lawv muaj qhov tseem ceeb Ser residue ntawm qhov chaw nquag uas yog qhov tseem ceeb rau catalysis. Qhov tseeb no Ser yog ntau reactive dua lwm yam serines nyob rau hauv cov protein.
