Serine protease inhibitors, lossis serpins, suav nrog ib tsev neeg ntawm cov proteins uas tiv thaiv kev ua haujlwm ntawm serine proteases. Cov proteins no inhibit protease kev ua los ntawm kev txuag cov txheej txheem uas cuam tshuam nrog kev hloov pauv loj (raws li kev tshuaj xyuas hauv Miranda thiab Lomas, 2006; Wang li al., 2008; thiab Ricagno li al., 2009).
Protease inhibitor ua dab tsi?
Protease inhibitors, uas suav nrog cov tshuaj tseem ceeb siv los kho HIV, ua haujlwm los ntawm kev khi rau cov enzymes proteolytic (proteases). Qhov ntawd thaiv lawv lub peev xwm ua haujlwm. Protease inhibitors tsis kho HIV. Tab sis los ntawm kev thaiv cov protease, lawv tuaj yeem tiv thaiv HIV los ntawm kev tsim nws tus kheej.
Serine protease mechanism yog dab tsi?
Serine proteases (los yog serine endopeptidases) yog enzymes uas tshem peptide bonds hauv cov proteins, uas serine ua hauj lwm raws li nucleophilic amino acid ntawm (enzyme's) active site. Lawv pom nyob rau hauv ob qho tib si eukaryotes thiab prokaryotes.
Yuav ua li cas serine proteases ua haujlwm tiag tiag?
Nws tau sib cav tias serine proteases thiab lwm yam enzymes ua haujlwm los ntawm muab cov khoom siv hluav taws xob sib txuas ntxiv rau cov kev hloov pauv hauv kev faib tawm uas tshwm sim thaum cov tshuaj tiv thaiv lawv catalyze.
Puas yog serine protease inhibitors sib tw?
Feem ntau ntawm cov protease inhibitors yog sib tw inhibitors. Txawm hais tias muaj ntau lub hom phiaj thiab cov txheej txheem sib txawv ntawm inhibition, feem ntau cov protease inhibitors khi ib feem tseem ceeb ntawmtus inhibitor nyob rau hauv lub active site nyob rau hauv ib tug zoo li substrate (Daim duab 2).
