MF59 yog ib qho tshuaj tiv thaiv kab mob uas siv cov derivative ntawm shark siab roj hu ua squalene. Nws yog Novartis 'proprietary adjuvant uas tau ntxiv rau cov tshuaj tiv thaiv kab mob khaub thuas los pab txhawb tib neeg lub cev tiv thaiv kab mob los ntawm kev tsim cov CD4 nco hlwb.
Yog MF59 nyab xeeb?
Nyob rau hauv tib neeg, MF59 yog tshuaj tiv thaiv muaj kev nyab xeeb thiab muaj zog tshaj plaws uas tau tso cai nyob hauv ntau dua 20 lub teb chaws (Fluad [Novartis Vaccines and Diagnostics Inc., MA, USA]). Kev nyab xeeb profile ntawm MF59-adjuvanted tshuaj tiv thaiv yog tsim tau zoo los ntawm kev ruaj ntseg database loj.
MF59 adjuvant ua haujlwm li cas?
Peb ntseeg tias MF59 ua haujlwm tseem ceeb los ntawm inducing a chemokine-driven immune amplification loop uas ua rau kev txhim kho cov xov tooj ntawm tes los ntawm cov ntshav mus rau qhov chaw tswj hwm, yog li txhim kho tag nrho cov lej ntawm antigen presenting cells (APCs) muaj nyob rau hauv qhov chaw txhaj tshuaj [14].
MF59 ua dab tsi hauv cov tshuaj tiv thaiv?
MF59 muaj kev nyab xeeb thiab ua tau zoo rau tib neeg. MF59-adjuvanted vaccination spares koob tshuaj tiv thaiv thiab txhim kho hemagglutination inhibiting antibodies tiv thaiv homologous thiab heterologous influenza virus hom.
MF59 ua li cas?
MF59 yog cov roj-hauv-dej emulsion muaj squalene thiab ob surfactants, Tween 80 thiab Span 85. Squalene yog cov roj uas tshwm sim hauv tib neeg lub siab thiab yog ib tug ncaj precursor rau cov cholesterol (23).
