Qhov kev kuaj tshuaj tiv thaiv dsDNA yog qhov tshwj xeeb rau lupus; Txawm li cas los xij, tsuas yog 65-85% ntawm cov neeg mob lupus tuaj yeem ua tau zoo; uas yog, qhov tsis zoo los tiv thaiv dsDNA tsis txiav txim siab lupus. Yog hais tias ib tug neeg muaj qhov zoo ANA, ib qho tshuaj tiv thaiv dsDNA yuav raug siv los ua qhov txawv ntawm lupus los ntawm lwm yam kab mob autoimmune uas muaj cov tsos mob zoo sib xws.
Dab tsi tuaj yeem ua rau muaj qhov zoo tiv thaiv dsDNA?
Qhov muaj cov tshuaj tiv thaiv dsDNA feem ntau qhia ntau dua mob lupus, xws li lupus nephritis (mob raum lupus). Thaum tus kab mob ua haujlwm, tshwj xeeb tshaj yog nyob rau hauv ob lub raum, muaj ntau cov tshuaj tiv thaiv DNA antibodies feem ntau tshwm sim.
Koj puas tuaj yeem kuaj pom tus mob lupus thiab tsis muaj nws?
Thaum cov neeg feem coob uas muaj lupus tau kuaj ANA zoo, feem ntau cov neeg uas muaj tus kab mob lupus tsis muaj lupus. Yog tias koj kuaj pom qhov zoo rau ANA, koj tus kws kho mob tuaj yeem qhia ntau yam tshuaj tiv thaiv kab mob.
Koj puas tuaj yeem muaj qhov tsis zoo los tiv thaiv dsDNA?
Qhov teeb meem nrog cov tshuaj tiv thaiv dsDNA ELISAs yog tias lawv feem ntau muab qhov tsis zoo-cov txiaj ntsig zoovim yog kev sib txuas ntawm cov tshuaj tiv thaiv kab mob (nrog rau qhov tsis zoo ntawm cov moieties) rau cov txheej txheem ua ntej (10, 11).
Dab tsi yog qhov zoo dsDNA?
Qhov txiaj ntsig zoo rau ob-kab DNA (dsDNA) IgG cov tshuaj tiv thaiv kab mob hauv cov ntsiab lus kho mob tsim nyog yog qhia ntawm systemic lupus erythematosus (SLE).