Lub hydrolysis ntawm urea tshwm sim hauv ob theem. Hauv thawj theem, ammonia thiab carbamate yog tsim. Carbamate spontaneously thiab sai hydrolyzes rau ammonia thiab carbonic acid. Kev ua urease nce pH ntawm nws ib puag ncig raws li ammonia tsim, uas yog qhov yooj yim.
Vim li cas urease nce pH?
Urease hauv peptic ulcers
Hauv plab muaj qhov nce hauv pH ntawm cov mucosal hauv ob sab phlu vim los ntawm urea hydrolysis, uas tiv thaiv kev txav ntawm hydrogen ions nruab nrab ntawm lub plab thiab lub plab lumen.
Puas urease txo pH?
Tus pH profile ntawm urease hauv cov kab mob tsis zoo, sib piv rau qhov dawb lossis urease saum npoo, qhia tau tias muaj kev ua haujlwm me me ntawm pH. Txawm li cas los xij, nrog nce acidity, kev ua haujlwm urease nce ntawm 10- thiab 20-fold raws li pH poob ntawm 6.0 txog 5.0, thiab tom qab ntawd tseem nyob ruaj khov mus rau pH 2.5 (10, 11).
YPH ntawm urease yog dab tsi?
Urease cov dej num tseem nyob tas li mus rau pH nruab nrab ntawm 2.5 thiab 3.0 thiab kuaj pom txawm tias pH ntawm 2.0.
H. pylori nce pH li cas?
Cov kab mob ua rau plab hnyuv Helicobacter pylori yog tib yam kab mob uas paub tias ua rau cov kab mob hnyav acidic ntawm tib neeg lub plab. H. pylori ciaj sia nyob rau hauv acidic tej yam kev mob los ntawm producing urease, uas catalyzes hydrolysis ntawm urea kom yield ammonia li elevating lub pH ntawm nws ib puag ncig.
