Sialic acids kuj muaj nyob rau hauv ntau tib neeg lub cev kua xws li qaub ncaug, gastric kua txiv, ntshav, zis, kua muag, thiab tib neeg mis nyuj (Table 2). Dawb sialic acid muaj nyob rau hauv cov zis, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob uas muaj tus kab mob sialuria, qhov twg mus txog 7 g ntawm sialic acid yuav raug tshem tawm nyob rau hauv 1 hnub (Montreuil li al, 1968).
sialic acid tuaj qhov twg?
Sialic acids feem ntau yog ib feem ntawm glycoproteins, glycolipids lossis gangliosides, qhov chaw uas lawv kho qhov kawg ntawm qab zib chains ntawm lub hlwb los yog cov proteins soluble. Txawm li cas los xij, sialic acids kuj tau pom hauv Drosophila embryos thiab lwm yam kab. Feem ntau, cov nroj tsuag zoo li tsis muaj lossis pom sialic acids.
Dab tsi muaj sialic acid?
Cov khoom noj khoom haus uas nplua nuj nyob hauv Neu5Gc suav nrog cov nqaij liab xws li nyuj, nqaij npuas, yaj, thiab rau qib qis dua, nyuj cov mis nyuj. Qhov tseem ceeb ntawm cov lus ceeb toom yog qhov tseeb tias cov nroj tsuag thiab cov nqaij qaib tsis muaj Neu5Gc, thiab cov qauv ntses uas tau kawm txog tam sim no muaj cov lej qis (58, 60).
Lub hom phiaj ntawm sialic acid yog dab tsi?
Sialic acids (Sias) yog cuaj-carbon atoms suab thaj feem ntau tshwm sim raws li cov seem ntawm glycoproteins thiab glycolipids ntawm lub xov tooj ntawm tes los yog zais cia. Lawv muaj lub luag haujlwm tseem ceeb hauv kev sib txuas lus ntawm tes thiab tseem tiv thaiv kab mob thiab ciaj sia ntawm cov kab mob.
Dab tsi yog sialic acid biology?
Sialic acids lossis N-acetylneuraminic acids (Neu5Ac) yog ntau pawg ntawm 9-carboncarboxylated monosaccharides synthesized nyob rau hauv cov tsiaj, tam sim no nyob rau sab nraud kawg ntawm N-txuas thiab O-linked carbohydrate chains thiab nyob rau hauv lipid-associated glycoconjugates (Fig. 1, 1-6) thiab tsis muaj cov nroj tsuag.
