Kev Kho Mob Txhais ntawm cytosine arabinoside: a cytotoxic antineoplastic agent C9H13N3 O5 uas yog cov isomer hluavtaws ntawm cov nucleoside tshwm sim ntawm cytosine thiab arabinose thiab yog siv tshwj xeeb hauv kev kho mob myelogenous leukemia hauv cov neeg laus. - hu ua Ara-C.
cytosine arabinoside ua haujlwm li cas?
Cytosine arabinoside yog pyrimidine nucleoside antimetabolite. Intracellularly nws hloov mus rau hauv cytarabine triphosphate, uas sib tw nrog deoxycytidine triphosphate thiab inhibits DNA polymerase nrog ua rau inhibition ntawm DNA synthesis. Nws yog tus neeg sawv cev ntawm lub voj voog tshwj xeeb ua haujlwm nyob rau theem S.
YPuas yog cytarabine tib yam li cytosine arabinoside?
Cytarabine, tseem hu ua cytosine arabinoside (ara-C), yog cov tshuaj khomob uas siv los kho tus mob myeloid leukemia (AML), mob qog ntshav qog ntshav qog ntshav (TSIS), mob qog noj ntshav myelogenous leukemia (CML), thiab tsis yog Hodgkin's. lymphoma.
Yuav ua li cas yog lub luag haujlwm ntawm kev ua ntawm cytarabine?
Mechanism of Action
Cytarabine yog ib qho pyrimidine analog thiab tseem hu ua arabinosylcytosine (ARA-C). Nws tau hloov mus rau hauv daim ntawv triphosphate hauv lub cell thiab sib tw nrog cytidine los koom nrog nws tus kheej hauv DNA. Cov piam thaj moiety ntawm cytarabine cuam tshuam kev sib hloov ntawm cov molecule hauv DNA.
YCytarabine yog tsim los ntawm dab tsi?
Cytarabine (Cytosar) yog ib qho sib caislos ntawm hiav txwv daim txhuam cev. Nws kuj tau raug xa mus rau cytosine arabinoside thiab Ara-C. Cytarabine yog metabolized rau cov tshuaj nquag uas inhibits DNA synthesis. Cytarabine yog ib qho tshuaj tiv thaiv metabolite hluavtaws nucleoside analogue.
