Isoniazid yuav luag tag nrho nqus los ntawm kab mob plab, thiab cov koob tshuaj pom zoo ua tiav qib kho hauv txhua lub cev nqaij thiab kua dej, suav nrog CSF.
YYuav ua li cas isoniazid nqus tau?
Absorption: nrawm thiab nqus tag nrho los ntawm GI ib puag ncig tom qab kev tswj hwm qhov ncauj. INH kuj yog nqus tau yooj yim tom qab I. M. txhaj tshuaj. Kev faib tawm: faib dav rau hauv cov ntaub so ntswg hauv lub cev thiab cov kua dej, suav nrog ascitic, synovial, pleural, thiab cerebrospinal kua; lub ntsws thiab lwm yam kabmob; thiab hnoos qeev thiab qaub ncaug.
Yuav ua li cas yog lub tswv yim ntawm kev ua ntawm isoniazid?
Mechanism of action - Cov tshuaj tua kab mob ntawm INH yog xaiv rau mycobacteria, zoo li vim nws lub peev xwminhibit mycolic acid synthesis, uas cuam tshuam nrog cell phab ntsa synthesis, yog li tsim tau Cov kab mob bactericidal [1].
YPuas isoniazid soluble hauv dej?
Solubility: 1 g hauv 8 g dej, 1 g hauv 50 mL cawv; me ntsis soluble hauv chloroform thiab me ntsis soluble hauv ether. A 10% tov muaj pH ntawm 6.0 txog 8.0.
Lub hom phiaj ntawm isoniazid yog dab tsi?
Cov tshuaj tiv thaiv tubercular nyiam isoniazid tshwj xeeb yog lub hom phiaj long-chain enoyl-acyl carrier protein reductase (InhA), enzyme tseem ceeb rau mycolic acid biosynthesis hauv Mycobacterium tuberculosis.
