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2024 Tus sau: Elizabeth Oswald | [email protected]. Kawg hloov kho: 2024-01-13 00:07
Isoniazid yuav luag tag nrho nqus los ntawm kab mob plab, thiab cov koob tshuaj pom zoo ua tiav qib kho hauv txhua lub cev nqaij thiab kua dej, suav nrog CSF.
YYuav ua li cas isoniazid nqus tau?
Absorption: nrawm thiab nqus tag nrho los ntawm GI ib puag ncig tom qab kev tswj hwm qhov ncauj. INH kuj yog nqus tau yooj yim tom qab I. M. txhaj tshuaj. Kev faib tawm: faib dav rau hauv cov ntaub so ntswg hauv lub cev thiab cov kua dej, suav nrog ascitic, synovial, pleural, thiab cerebrospinal kua; lub ntsws thiab lwm yam kabmob; thiab hnoos qeev thiab qaub ncaug.
Yuav ua li cas yog lub tswv yim ntawm kev ua ntawm isoniazid?
Mechanism of action - Cov tshuaj tua kab mob ntawm INH yog xaiv rau mycobacteria, zoo li vim nws lub peev xwminhibit mycolic acid synthesis, uas cuam tshuam nrog cell phab ntsa synthesis, yog li tsim tau Cov kab mob bactericidal [1].
YPuas isoniazid soluble hauv dej?
Solubility: 1 g hauv 8 g dej, 1 g hauv 50 mL cawv; me ntsis soluble hauv chloroform thiab me ntsis soluble hauv ether. A 10% tov muaj pH ntawm 6.0 txog 8.0.
Lub hom phiaj ntawm isoniazid yog dab tsi?
Cov tshuaj tiv thaiv tubercular nyiam isoniazid tshwj xeeb yog lub hom phiaj long-chain enoyl-acyl carrier protein reductase (InhA), enzyme tseem ceeb rau mycolic acid biosynthesis hauv Mycobacterium tuberculosis.
Pom zoo:
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Tom qab kaum xyoo ntawm kev tshawb nrhiav cov tswv yim tshiab los ua qhov kev tshawb xav gravitational sib haum nrog tus ntsuj plig ntawm kev sib raug zoo tshwj xeeb, Einstein tuaj nrog txoj kev xav ntawm kev sib raug zoo (1915), tus qauv ntawm tag nrho cov niaj hnub gravitational theories.
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Kev nqus cov tshuaj corticosteroidrau ob mus rau peb lub hlis yog qhov ua tau ntev, thiab tej zaum yuav yog ib qho kev kho mob zoo rau qee cov neeg mob sarcoidosis. Puas nqus nqus pa ua haujlwm rau sarcoidosis? kev kho mob rau sarcoidosis suav nrog:
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Nov yog lo lus nug zoo. Yog tias koj cev xeeb tub thawj zaug, nws yuav yog qhov zoo tshaj plaws los siv cov tampon qis tshaj plaws (feem ntau sau tias yog nyias, lub teeb, lossis junior). Cov qhov loj me no feem ntau nyiam dua thiab tuaj yeem nkag tau yooj yim dua rau cov neeg tshiab rau cov txheej txheem.
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Thaum ntau txhiab tus neeg nce toj tau ua tiav Mount Everest, qhov chaw siab tshaj plaws hauv ntiaj teb, tsuas yog ob tus neeg tau nqis mus raulub ntiaj teb qhov chaw tob tshaj plaws, Challenger Deep hauv Dej Hiav Txwv Pacific Mariana Trench.