Mechanism of action - Cov tshuaj tua kab mob ntawm INH yog xaiv rau mycobacteria, zoo li vim nws lub peev xwminhibit mycolic acid synthesis, uas cuam tshuam nrog cell phab ntsa synthesis, yog li tsim tau Cov kab mob bactericidal [1].
Qhov twg yog cov txheej txheem ntau tshaj plaws rau isoniazid tsis kam?
Ob lub ntsiab molecular mechanisms ntawm isoniazid tsis kam yog txuam nrog noob hloov hauv katG thiab inhA lossis nws thaj tsam txhawb nqa. Tseeb tiag, ntau qhov kev tshawb fawb tau pom kev hloov pauv hauv ob lub noob no yog qhov feem ntau cuam tshuam nrog isoniazid tsis kam [25, 26].
YYuav ua li cas yog lub mechanism ntawm kev txiav txim ntawm pyrazinamide?
Hauv vitro thiab hauv vivo, cov tshuaj tsuas yog ua haujlwm ntawm cov kua qaub me ntsis pH. Pyrazinamie tau qhib rau Pyrazinoic acid nyob rau hauv bacilli qhov twg nws cuam tshuam nrog fatty acid synthase FAS I. Qhov no cuam tshuam nrog cov kab mob muaj peev xwm los tsim cov fatty acids tshiab, xav tau kev loj hlob thiab rov ua dua.
Yuav ua li cas yog lub tswv yim ntawm kev ua ntawm rifampicin?
Mechanism ntawm kev ua - Rifampin yog xavtxwv tsis pub cov kab mob DNA-nyob ntawm RNA polymerase, uas zoo li tshwm sim los ntawm cov tshuaj khi rau hauv polymerase subunit tob hauv DNA / RNA channel, txhawb nqa ncaj qha thaiv ntawm elongating RNA [3]. Cov nyhuv no yog xav tias muaj feem cuam tshuam nrog [4].
Yuav ua li cas yog qhov kev ua ntawm ethambutol?
Mechanism of action
Ethambutol yogbacteriostatic tiv thaiv kev loj hlob TB bacilli. Nws ua haujlwm los ntawm kev cuam tshuam kev tsim cov phab ntsa ntawm tes. Mycolic acids txuas rau 5'-hydroxyl pawg ntawm D-arabinose residues ntawm arabinogalactan thiab tsim mycolyl-arabinogalactan-peptidoglycan complex nyob rau hauv lub cell phab ntsa.
