Cardiotoxicity ntawm trastuzumab yog suav tias yog qhov tshwm sim ntawm attenuated HER2-mediated signaling hauv plawv, ua rau txo qis kev ua haujlwm ntawm lub plawv myocytes. HER2 zoo nkaus li ua haujlwm raws li cov txheej txheem them nyiaj ua haujlwm tiv thaiv kev ntxhov siab, xws li anthracycline-induced cardiotoxicity.
Vim li cas Herceptin ua rau mob plawv?
Thaum kev kho mob Herceptin, uas tau pom zoo rau ib xyoos, tshuaj lom tuaj yeem ua rau lub plawv tsis muaj zog los nqus ntshav. Txhua tus neeg mob ntawm Herceptin tau kuaj mob plawv tsis tu ncua, xws li echocardiogram, txhawm rau nrhiav kev puas tsuaj rau lub plawv.
YPuas Herceptin ua rau mob plawv?
Ib yam li ntawd, kev tshuaj xyuas zaum kawg los ntawm HERceptin Adjuvant sim kuj tau tshaj tawm ntau tus nqi qis ntawm cardiotoxicitynrog 7.25% qhov tshwm sim ntawm theem nrab plawv kawg (chav kawm I lossis II toxicity raws li tau hais los ntawm New York Heart Association) hauv 2-xyoo trastuzumab pawg thiab 4.4% hauv 1-xyoo trastuzumab [16].
Herceptin cuam tshuam li cas rau lub siab?
Ib qho kev mob tshwm sim ntawm lub mis mob qog noj ntshav trastuzumab (Herceptin) yog tias nws tuaj yeem ua rau lub plawv thiab nws lub peev xwm los tso ntshav tau zoo, qee zaum ua rau lub plawv mob. tsis ua hauj lwm, suav nrog ua tsis taus pa thiab mob hauv siab.
Vim li cas trastuzumab cuam tshuam rau lub siab?
Pib pob ntxig, trastuzumab tuaj yeem ua rau sab laug ventricular tsis ua haujlwm, arrhythmias, kub siab,Disabling plawv tsis ua hauj lwm, cardiomyopathy thiab plawv tuag.