Thrombin hloov Fibrinogen → Fibrin, tsim "_clot." Fibrin tsim cov ntaub ntawv polymers (ntau ntxiv ntawm qhov no los tom ntej). Nws yog cov khoom siv coagulation, thiab lub hom phiaj ntawm coagulation cascade. Activates Factor VIII → VIIIa rau siv rau hauv txoj kev nkag siab (pib hauv qab).
Dab tsi ua rau thrombin qhib thaum lub sijhawm coagulation?
Activated thrombin ua rau txhawm rau tshem tawm ntawm fibrinogen rau hauv fibrin monomersuas, thaum polymerization, tsim cov fibrin clot. Yog li, kev ua kom prothrombin yog qhov tseem ceeb hauv lub cev thiab cov kab mob pathophysiological coagulation.
Dab tsi ua kom thrombin los ntawm prothrombin?
Thrombin yog tsim los ntawm cov enzymatic cleavage ntawm ob qhov chaw ntawm prothrombin los ntawm activated Factor X (Xa). Cov kev ua ntawm Factor Xa tau zoo heev los ntawm kev khi rau activated Factor V (Va), hu ua prothrombinase complex.
Cov coagulation ua haujlwm li cas?
Txoj kev sib cuag ntawm coagulation yog pib los ntawm ua kom muaj txiaj ntsig XII (fXII) hauv cov txheej txheem uas tseem cuam tshuam nrog cov qib siab molecular-yuag kininogen (HK) thiab plasma prekallikrein (PK.).
Lub luag haujlwm ntawm thrombin hauv cov ntshav txhaws yog dab tsi?
thrombin hloov fibrinogen rau fibrin. 5. Factor XIIIa nkoos tsim ntawm insoluble fibrin clot.
