Thrombin tseem yog tus neeg nruab nrab ntawm platelet activation, tso tawm cov tshuaj tiv thaiv thiab kev sib sau. Nws qhov kev txiav txim ntawm cov platelets ua kom muaj txiaj ntsig catalytic nto rau cov tiam tom ntej ntawm thrombin.
Platelets puas tsim thrombin?
Txawm hais tias platelets tsis tuaj yeem muaj TF, lawv tuaj yeem tsim cov thrombin los ntawm TF txoj kev ywj pheej[2]. Vim hais tias TF qhia los ntawm vascular hlwb induces intravascular thrombosis [9], nyob rau hauv txoj kev tshawb no, peb siv ib tug intrinsic coagulation system, tsis muaj sab nraud TF.
Platelets tso dab tsi?
Platelets secrete ntau yam cuam tshuam nrog coagulation thiab kho qhov txhab. Thaum lub sij hawm coagulation, lawv tso tawm yam uas ua rau kom cov platelet aggregation hauv zos (thromboxane A), kho mob o (serotonin), thiab txhawb cov ntshav coagulation los ntawm kev nce thrombin thiab fibrin (thromboplastin)..
Pob activated platelets tso thrombin?
TxA2 tsim tawm thiab tso tawm los ntawm cov platelets stimulated kuj tseem ua kom cov platelets ntxiv ntawm GPCR, yog li txhawb kev tsim cov ntsaws. Thrombin yog cov platelet agonist uas muaj zog tshaj plaws thiab tseem muaj lub luag haujlwm rau hloov fibrinogen rau hauv fibrin kom stabilize cov platelet plugs [5, 6, 9, 13].
Thrombin tso tawm li cas?
cov ntaub so ntswg sab nraud ntawm lub nkoj txhawb nqa cov khoom tsim thrombin los ntawm kev ua kom lub zog ntawm cov hlab ntsha. Thrombin ua rau platelet aggregation. Platelets raug rau thrombinzais lawv cov granules thiab tso cov ntsiab lus ntawm cov granules rau hauv cov ntshav plasma.
