Kinases kho qhov hloov pauv ntawm phosphate moiety los ntawm lub zog siab molecule (xws li ATP) rau lawv cov molecule substrate, raws li pom hauv daim duab hauv qab no. Kinases yuav tsum tau ua kom ruaj khov qhov kev tawm tsam no vim tias daim ntawv cog lus phosphoanhydride muaj lub zog siab.
Puas protein kinases xav tau ATP?
Protein kinases (PTKs) yog cov enzymes uas tswj cov kev ua haujlwm lom neeg ntawm cov proteins los ntawm phosphorylation ntawm cov amino acids tshwj xeeb nrog ATPua qhov chaw ntawm phosphate, yog li inducing ib tug conformational hloov los ntawm ib tug Tsis muaj zog rau daim ntawv nquag ntawm cov protein.
Yuav ua li cas protein kinases qhib?
Kev ua haujlwm yog kho los ntawm kev khi ntawm cyclic AMP rau cov tswj hwm subunits, uas ua rau tso tawm cov catalytic subunits. cAPK feem ntau yog cov protein cytoplasmic, tab sis thaum ua kom nws tuaj yeem txav mus rau hauv lub nucleus, qhov chaw nws phosphorylates cov protein tseem ceeb rau kev tswj cov noob. Domain txav hauv cov protein kinases.
YPob kinases Hydrolyse ATP?
Kinases yog cov enzymes uas couple hydrolysis ntawm ATP rau ntxiv ntawm pab pawg phosphate rau nws cov substrate.
Kinases tswj hwm li cas?
Protein kinases thiab phosphatase yog tswj los ntawm protein-protein kev sib cuam tshuam, khi ntawm ligands, thiab thim rov qab lossis hloov tsis tau cov kev hloov pauv xws li phosphorylation thiab txwv proteolysis.
