Lub hnab ntawv noob ntawm tib neeg kev tiv thaiv kab mob virus hom 1 (HIV-1) txiav txim siab lub cell tropism ntawm tus kab mob (11, 32, 47, 62), kev siv tshuaj chemokine receptors ua cofactors rau viral nkag (4, 17), thiab lub peev xwm ntawm tus kab mob no induce syncytia nyob rau hauv cov kab mob hlwb (55, 60).
Puas HIV qhia tropism?
HIV tropism (hom CD4 cell uas tus kab mob yuav kis tau) yog txiav txim siab los ntawm hom coreceptor lees paub los ntawm gp120. Kev khi rau CCR5 yog hu ua CCR5 (los yog R5) tropism, thaum khi rau CXCR4 yog hu ua CXCR4 (los yog X4) tropism. Cov duab thiab kab mob qauv tsim los ntawm Louis E. Henderson, PhD.
HIV hloov tropism li cas?
Raws li hom coreceptor, HIV nthuav tawm cov tropisms sib txawv. HIV feem ntau xav tau CCR5 los pab txhawb kev kis kab mob2, tab siskwv yees li ib nrab ntawm cov neeg muaj tus kab mob yuav hloov mus rau kev siv CXCR4 , uas feem ntau cuam tshuam nrog kev poob nrawm. nyob rau hauv CD4+ xov tooj ntawm tes thiab cov kab mob sai sai 3 , 4.
Dab tsi txiav txim siab tus tswv tsev cell tropism rau HIV?
Lub cellular tropism ntawm HIV yog qhov loj heev txiav txim siab los ntawm lub xov tooj ntawm tes receptorsnws siv rau kev khi thiab nkag. HIV kis tau thiab thaum kawg rhuav tshem T-helper lymphocytes tab sis tsis yog T-killer lymphocytes, vim T-helper hlwb nthuav qhia CD4 qhov cytotoxic T-cells qhia CD8.
YPuas HIV muaj cellularstructure?
HIV (Human Immunodeficiency Virus) yog tsim los ntawm ob kab ntawm RNA, 15 hom kab mob proteins, thiab ob peb cov proteins los ntawm lub xov tooj ntawm tes kawg uas nws kis tau, txhua tus nyob ib puag ncig. ib lipid bilayer membrane.
