Busulfan yog alkylsulfonate. Nws yog tus neeg sawv cev alkylating uas tsim DNA-DNA interstrand crosslinks ntawm DNA bases guanine thiab adenine thiab nruab nrab ntawm guanine thiab guanine. Qhov no tshwm sim los ntawmSN2 cov tshuaj tiv thaiv uas cov nucleophilic guanine N7 tawm tsam cov pa roj carbon uas nyob ib sab ntawm mesylate tawm hauv pawg.
Dab tsi yog kev faib tshuaj rau busulfan?
Busulfan yog nyob rau hauv cov tshuaj hu ua alkylating agents. Nws ua haujlwm los ntawm kev qeeb lossis nres kev loj hlob ntawm cov qog nqaij hlav hauv koj lub cev.
Puas yog busulfan lom?
Busulfan yog thawj cov tshuaj cytotoxic tshaj tawm koom nrog kev mob ntsws ntsws [1]. Cov qauv qhia ntawm pulmonary toxicity muaj xws li mob ntsws mob, mob interstitial fibrosis, thiab alveolar hemorrhage.
Dab tsi yog qhov txiaj ntsig tseem ceeb ntawm busulfan?
Side Effects
Ntaus, ntuav, raws plab, cem quav, tsis qab los, qhov ncauj, mob plab / plab, kiv taub hau, o pob taws / taw / tes, dej ntws, mob taub hau, lossis teeb meem pw tsaug zog tuaj yeem tshwm sim. Yog tias ib qho ntawm cov teebmeem no tshwm sim los yog hnyav dua, qhia rau koj tus kws kho mob lossis tus kws muag tshuaj tam sim ntawd. Kev xeev siab thiab ntuav tuaj yeem hnyav.
Yam tshuaj busulfan hom kev ua yog dab tsi?
MECHANISM OF ACTION:
Busulfan yog bfunctional alkylating agent. 3-5 Tom qab lub cev nqus dej, carbonium ions tau tsim sai, ua rau alkylation ntawm DNA.
