Acyl-CoA ces thauj mus rau hauv mitochondria ntawm carnitine shuttle ua ntej β-oxidation voj voog tuaj yeem tshwm sim. Carnitine palmitoyl transferase (CPT) I, ib txheej mitochondrial membrane protein, hloov acyl-CoA rau hauv acylcarnitine uas thauj los ntawm carnitine acylcarnitine translocase rau hauv mitochondrion.
Acetyl-CoA thauj mus li cas?
Acetyl-CoA yog tsiv los ntawm mitochondrial membrane, thiab nkag mus rau hauv cytoplasm ntawm tes, raws li cov molecule citrate. Hauv cytoplasm, cov citrate molecules no tau hloov dua siab tshiab rov qab mus rau acetyl-CoA. Cov tshuaj tiv thaiv no xav kom lub cell siv qee lub zog los ntawm kev rhuav tshem ATP molecule.
Acetyl-CoA shuttle system yog dab tsi?
Yuav tsum thauj, acetyl-CoA yuav tsum tau hloov pauv mus rau citric acid siv txoj hauv kev hu ua tricarboxylate thauj system. Hauv mitochondria, enzyme citrate synthase koom nrog acetyl-CoA nrog oxaloacetate los ua citrate.
Dab tsi ua rau acetyl-CoA?
Acetyl-CoA yog tsim los ntawm oxidative decarboxylation ntawm pyruvate los ntawm glycolysis, uas tshwm sim hauv mitochondrial matrix, los ntawm oxidation ntawm cov saw ntev fatty acids, los yog oxidative degradation ntawm tej yam amino acids. Acetyl-CoA ces nkag mus rau hauv lub voj voog TCA uas nws tau oxidized rau lub zog tsim.
Acetyl-CoA thauj tawm ntawm mitochondria li cas rau fatty acid synthesis?
Fatty acidbiosynthesis tshwm sim hauv cytosol, yog li acetyl CoA yuav tsum tau thauj mus rau cytosol los ntawm mitochondria. Raws li nws tsis tuaj yeem hla daim nyias nyias, nws raug thauj tawm ntawm mitochondria li citrate. Citrate yog tsim los ntawm condensation ntawm acetyl CoA nrog oxaloacetate los ntawm enzyme citrate synthase.
