β-Lactams tseem yog ib qho ntawm cov tshuaj feem ntau koom nrog hauv cov tshuaj tsis haum tshuaj. Plaub pawg tseem ceeb sib koom ua ke plaub-tus tswv cuab β-lactam nplhaib; thiab yog tias lub nplhaib no tau sib xyaw ua ke rau a thiazolidine nplhaib, β-lactam raug cais ua penicillin. Qhov no suav nrog piperacillin thiab antistaphylococcal penicillins.
Dab tsi yog beta-lactam nplhaib hauv penicillin?
Lub nplhaib β-lactam yog ib feem ntawm cov qauv tseem ceeb ntawm ntau tsev neeg tshuaj tua kab mob, cov thawj coj yog penicillins, cephalosporins, carbapenems, thiab monobactams, uas yog, yog li ntawd, kuj hu ua β-lactam tshuaj tua kab mob. Yuav luag tag nrho cov tshuaj tua kab mob no ua haujlwm los ntawm inhibiting kab mob cell phab ntsa biosynthesis.
Lub nplhaib beta-lactam ua haujlwm li cas hauv penicillin?
Penicillin thiab feem ntau lwm yam tshuaj tua kab mob β-lactam ua by inhibiting penicillin-binding proteins, uas ib txwm ua rau kev sib txuas ntawm cov kab mob ntawm phab ntsa. Thaum tsis muaj β-lactam tshuaj tua kab mob (sab laug), phab ntsa ntawm tes ua lub luag haujlwm tseem ceeb hauv kev tsim cov kab mob.
Qhov twg heterocycle yog fused nrog beta-lactam nplhaib hauv cov qauv ntawm cephalosporin?
In penicillins, cephalosporins, thiab carbapenems, lub nplhaib no yog fused rau lwm 5- lossis 6-tus tswv cuab lub nplhaib, whereas hauv monobactams, lub nplhaib β-lactam yog monocyclic (Daim duab 1).
Lub nplhaib dab tsi muaj nyob hauv penicillin?
Tus yam ntxwv tseem ceeb ntawm covpenicillins yog lub four-membered β-lactam nplhaib; Cov qauv moiety no yog qhov tseem ceeb rau penicillin cov tshuaj tua kab mob. Lub nplhaib β-lactam yog nws tus kheej fused rau tsib lub nplhaib thiazolidine.
