Tetraethylammonium (TEA) yog ib qho yooj yim quaternary ammonium compound. Nws yog feem ntau siv sim los thaiv cov kab poov tshuaj (Hille, 2001). TEA molecule xav tias lub cev nkag mus rau hauv lub pore thiab thaiv cov channel.
Tetraethylammonium cuam tshuam li cas muaj peev xwm ua tau?
da dej thov ntawm tetraethylammonium (TEA, 1-10 mM) depolarized lub peev xwm so, ua kom lub peev xwm ua tau ntevthiab nce qhov amplitude thiab lub sijhawm ntawm qhov ua rau passive depolarizing tom qab muaj peev xwm. (DAP) nyob rau hauv ib koob tshuaj-raws li thiab thim rov qab.
TEA puas thaiv cov poov tshuaj xau channel?
TEA yog cov tshuaj tiv thaiv kab mob potassium siv los soj ntsuam cov qauv thiab kev ua haujlwm ntawm cov poov tshuaj channel1. Nws inhibits potassium channel ua haujlwm los ntawm kev khi hauv txoj kev ion conduction thiab cuam tshuam cov poov tshuaj txaus. Nws tuaj yeem khi rau ntawm ob sab ntawm daim nyias nyias nrog cov khoom sib txawv ntawm txhua qhov chaw khi.
Passium channel blockers ua dab tsi?
Potassium channel blockers yog siv los kho supraventricular thiab ventricular arrhythmias, ua rau muaj kev phom sij rau lub neej, thiab atrial fibrillation thiab flutter.
TEA cuam tshuam li cas neuron muaj nuj nqi?
Tetraethyl ammonium (TEA), quaternary ammonium cation, yog ib tus neeg sawv cev uas inhibits the voltage-gated K+ channels ntawm neurons. Raws li ib tug blocker ntawm voltage-gated K+cov channels, TEA muaj txiaj ntsig zoo hauv kev piav qhia lub luag haujlwm K+ channels ua si hauv cov peev txheej neuronal (saib daim duab 1).
