Oligodendrocytes yog cov hlwb hauv nruab nrab paj hlwb (CNS) uas tsim myelin. Hauv Ntau Yam Sclerosis (MS), oligodendrocytes raug puas tsuaj thiab myelin uas feem ntau cuam tshuam cov axons ntawm paj hlwb ploj, txheej txheem hu ua demyelination.
Yuav ua li cas rau oligodendrocytes hauv ntau yam sclerosis?
Yuav ua li cas rau oligodendrocytes hauv MS? Hauv MS, lub cev lub cev tiv thaiv kab mob xav tias oligodendrocytes yog kis kab mob thiab tawm tsam lawv thiab lawv cov myelin. Qhov no txhais tau hais tias cov paj hlwb raug cuam tshuam rau kev puas tsuaj, thiab cov lus tsis tuaj yeem nkag mus tau zoo, lossis tsis tuaj yeem dhau los.
Puas oligodendrocytes cuam tshuam rau ntau yam sclerosis?
Hauv MS, myelin-forming oligodendrocytes (OLGs) yog lub hom phiaj ntawm kev mob thiab tiv thaiv kab mob. OLG tuag los ntawm apoptosis lossis necrosis ua rau lub cell poob pom hauv MS plaques.
Vim li cas oligodendrocytes tsom rau ntau yam sclerosis?
Oligodendrocyte progenitor cells tuaj yeem sib txuas lus nrog lub cev tiv thaiv kab mob thiab ua rau lawv hloov lawv tus cwj pwm. Oligodendrocyte precursor cells tshem tawm cov khib nyiab myelin thiab cuam tshuam nrog lub cev tiv thaiv kab mobnyob rau hauv cov ntsiab lus ntawm myelin puas (raws li nyob rau hauv ntau yam sclerosis).
Oligodendrocytes puas hauv MS li cas?
Cell death yog txoj hmoo zoo ntawm oligodendrocytes hauv MS lesions [3, 8, 46]. T cell- thiab antibody-mediated kev raug mob feem ntau ua rauKev puas tsuaj ib txhij ntawm oligodendrocytes thiab myelin. Qee cov oligodendrocytes tuaj yeem muaj sia nyob qhov pib mob tshwm sim txawm tias muaj kev puas tsuaj ntawm lawv cov myelin sheaths.
