Ib txoj kev hloov pauv dav dav. Cov coenzyme, pyridoxal phosphate (PLP),txuas rau apoenzyme(enzyme tsis muaj coenzyme lossis cofactor) los ntawm pawg ε-amino (ε=epsilon) ntawm lysine residue hauv qhov chaw nquag, raws li qhia nyob rau hauv lub thib ob sab laug qauv; qhov txuas no hu ua Schiff puag (aldimine).
Pyridoxal phosphate ua dab tsi hauv cov tshuaj tiv thaiv transamination?
Pyridoxal phosphate ua ua coenzyme hauv txhua qhov kev hloov pauv, thiab hauv qee qhov oxylation thiab deamination ntawm cov amino acids. Cov pab pawg aldehyde ntawm pyridoxal phosphate tsim ib qho kev sib txuas ntawm Schiff-pawg nrog epsilon-amino pawg ntawm ib pawg lysine tshwj xeeb ntawm aminotransferase enzyme.
pyridoxal phosphate ua dab tsi?
Pyridoxal phosphate thiab pyridoxamine phosphate, lub catalytically active cov ntaub ntawv ntawm vitamin B (6),ua rau lub hlwb ua haujlwmlos ntawm kev koom tes ntawm theem hauv cov metabolism ntawm cov proteins, lipids, carbohydrates, lwm yam coenzymes. thiab cov tshuaj hormones.
Yuav ua li cas hauv qab no yuav tsum muaj pyridoxal phosphate ua coenzyme?
Nov yog daim ntawv nquag ntawm VITAMIN B 6 ua haujlwm ua coenzyme rau kev sib txuas ntawm cov amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Thaum lub sij hawm transamination ntawm amino acids, pyridoxal phosphate yog transiently hloov mus rau hauv pyridoxamine phosphate.(PYRIDOXAMINE).
Cov tshuaj tiv thaiv dab tsi pyridoxal phosphate catalyze?
Lawv catalyze ntau yam tshuaj tiv thaiv suav nrog racemization, hloov pauv, decarboxylation, tshem tawm, retro-aldol cleavage, Claisen condensation, thiab lwm yam ntawm cov substrates uas muaj cov amino pawg, feem ntau. α-amino acids.
