Nifedipine yuav luag tag nrho los ntawm kab mob plabraws li qhia los ntawm qib ntshav qab zib tom qab kev tswj hwm qhov ncauj, qhov ncauj, thiab qhov quav. Vim hais tias ntawm presystemic metabolism, lub bioavailability yog hais txog 56% mus rau 77%.
Nifedipine metabolism nyob qhov twg?
Kev faib tawm: Kwv yees li 92% mus rau 98% ntawm kev ncig nifedipine yog khi rau cov ntshav plasma proteins. Metabolism: Metabolized hauv lub siab. Excretion: Tawm hauv cov zis thiab quav raws li cov metabolites tsis ua haujlwm. Kev tshem tawm ib nrab-lub neej yog 2 mus rau 5 teev.
Nifedipine ua haujlwm hauv lub cev li cas?
Nifedipine yog ib hom tshuaj hu ua calcium channel blocker. Yog tias koj muaj ntshav siab, nws ua haujlwm los ntawm kev thaiv cov calcium uas nkag mus rau hauv cov leeg hauv plawv thiab cov hlab ntsha. Cov leeg xav tau calcium kom cog lus, yog li thaum koj thaiv cov calcium, nws ua rau cov leeg hlwb so.
Nifedipine soluble hauv dab tsi?
Nifedipine yog soluble hauv cov kuab tshuaj organic xws li ethanol, DMSO, thiab dimethyl formamide (DMF), uas yuav tsum tau purged nrog cov roj inert. Lub solubility ntawm nifedipine hauv ethanol yog kwv yees li 3 mg / ml thiab kwv yees li 30 mg / ml hauv DMSO thiab DMF. Nifedipine yog me ntsis soluble hauv aqueous buffers.
YPuas yog nifedipine yog CYP3A4 inhibitor?
Inhibition of CYP3A4
Cov nyhuv inhibitory ntawm nifedipine ntawm CYP3A4 kev ua haujlwm yog pom hauv daim duab 1. Nifedipine inhibited CYP3A4 kev ua haujlwm nyob rau hauv qhov concentration-dependentyam. Nifedipine tiv thaiv CYP3A4 nrog IC 50 tus nqi ntawm 7.8 μM.
