2024 Tus sau: Elizabeth Oswald | [email protected]. Kawg hloov kho: 2024-01-13 00:07
Nifedipine yuav luag tag nrho los ntawm kab mob plabraws li qhia los ntawm qib ntshav qab zib tom qab kev tswj hwm qhov ncauj, qhov ncauj, thiab qhov quav. Vim hais tias ntawm presystemic metabolism, lub bioavailability yog hais txog 56% mus rau 77%.
Nifedipine metabolism nyob qhov twg?
Kev faib tawm: Kwv yees li 92% mus rau 98% ntawm kev ncig nifedipine yog khi rau cov ntshav plasma proteins. Metabolism: Metabolized hauv lub siab. Excretion: Tawm hauv cov zis thiab quav raws li cov metabolites tsis ua haujlwm. Kev tshem tawm ib nrab-lub neej yog 2 mus rau 5 teev.
Nifedipine ua haujlwm hauv lub cev li cas?
Nifedipine yog ib hom tshuaj hu ua calcium channel blocker. Yog tias koj muaj ntshav siab, nws ua haujlwm los ntawm kev thaiv cov calcium uas nkag mus rau hauv cov leeg hauv plawv thiab cov hlab ntsha. Cov leeg xav tau calcium kom cog lus, yog li thaum koj thaiv cov calcium, nws ua rau cov leeg hlwb so.
Nifedipine soluble hauv dab tsi?
Nifedipine yog soluble hauv cov kuab tshuaj organic xws li ethanol, DMSO, thiab dimethyl formamide (DMF), uas yuav tsum tau purged nrog cov roj inert. Lub solubility ntawm nifedipine hauv ethanol yog kwv yees li 3 mg / ml thiab kwv yees li 30 mg / ml hauv DMSO thiab DMF. Nifedipine yog me ntsis soluble hauv aqueous buffers.
YPuas yog nifedipine yog CYP3A4 inhibitor?
Inhibition of CYP3A4
Cov nyhuv inhibitory ntawm nifedipine ntawm CYP3A4 kev ua haujlwm yog pom hauv daim duab 1. Nifedipine inhibited CYP3A4 kev ua haujlwm nyob rau hauv qhov concentration-dependentyam. Nifedipine tiv thaiv CYP3A4 nrog IC 50 tus nqi ntawm 7.8 μM.
Pom zoo:
Qhov khoom nyob rau pem hauv ntej ntawm lub lens diverging nyob qhov twg?
Teb: Dav hlau daim iav Dav Hlau Daim iav Rau lub teeb rays tawm lub dav hlau daim iav, lub lub kaum sab xis ntawm kev xav sib npaug ntawm lub kaum sab xis ntawm qhov xwm txheej. … Daim duab tsim los ntawm daim iav dav hlau yog ib txwm virtual (lub ntsiab lus tias lub teeb rays tsis yog los ntawm daim duab), upright, thiab ntawm tib lub duab thiab loj npaum li cov khoom nws yog reflecting.
Kev tsis ncaj ncees nyob qhov twg yog qhov hem rau kev ncaj ncees nyob txhua qhov chaw?
Martin Luther King tau hais tias: “Kev tsis ncaj ncees nyob txhua qhov chaw yog kev hem thawj rau kev ncaj ncees nyob txhua qhov chaw. Peb raug ntes nyob rau hauv ib tug inescapable network ntawm kev sib nrig sib pab, khi nyob rau hauv ib lub tsoos tsho ntawm txoj hmoo.
Qhov twg yog qhov tsis txaus ntseeg nyob qhov twg?
Yuav muaj ob lub cev tsis zoo nyob rau hauv lub midbrain. Lawv yog symmetrically positioned, ib tug nyob rau ntawm ob sab ntawm lub midline ntawm lub hlwb, thiab lawv tsim ob lub pob nyob rau hauv lub posterior nto ntawm lub paj hlwb nyob rau hauv qab ntawm lub superior colliculi.
Qhov twg tag nrho cov nqi hluav taws xob nyob ntawm qhov kev siv nyiaj siab tshaj plaws yog qhov twg?
marginal utility is zero. Tag nrho cov nqi hluav taws xob yog siab tshaj thaum marginal utility yog xoom. Qhov no yog vim muaj ntau txoj cai ntawm kev txo qis marginal utility uas hais tias tus neeg siv khoom noj ntau thiab ntau qhov zoo, qhov ntxiv rau tag nrho cov nqi hluav taws xob poob.
Yuav ua li cas cov as-ham absorbed hauv cov hnyuv?
Villi uas kab phab ntsa ntawm txoj hnyuv me nqus cov as-ham rau hauv cov hlab ntsha ntawm cov hlab ntshav thiab lacteals ntawm lymphatic system. Villi muaj cov txaj capillary, nrog rau cov hlab ntsha lymphatic hu ua lacteals. Fatty acids absorbed los ntawm tawg-down chyme chyme Nrog ib tug pH ntawm kwv yees li 2, chyme tawm ntawm lub plab yog acidic heev.
