Nitrofurantoin siv thaum cev xeeb tub tseem muaj kev txhawj xeeb rau ntau qhov laj thawj. Cov tshuaj tua kab mob no tuaj yeem cuam tshuam rau glutathione reductase kev ua haujlwm thiab yog li tuaj yeem ua rau hemolytic anemia(analogous rau cov teeb meem nws ua rau cov neeg mob uas muaj piam thaj-6-phosphate dehydrogenase deficiency).
Puas muaj kev nyab xeeb noj nitrofurantoin thaum cev xeeb tub?
Nitrofurantoin feem ntau yog siv los kho cov kab mob urinary tract (UTIs) hauv cov poj niam cev xeeb tub. Kev nplij siab hauv kev xaiv cov tshuaj tua kab mob no los ntawm nws phooj ywg FDA cev xeeb tub qeb B ratingthiab keeb kwm ntev ntawm kev nyab xeeb thiab siv tau zoo.
YPuas yog nitrofurantoin contraindicated nyob rau hauv thawj peb lub hlis twg?
ACOG tau hloov Pawg Neeg Saib Xyuas Kev xav 294 (2011) nrog Pawg Neeg Saib Xyuas Kev Pom Zoo 717 (rov lees paub 2019) uas tseem pom zoo kom ceev faj siv sulfonamides thiab nitrofurantoin hauv thawj peb lub hlis twg ntawm cev xeeb tub vim kom muaj kev pheej hmoo ntawm kev yug menyuam., yog tias tsis muaj lwm txoj hauv kev.
Puas yog nitrofurantoin muaj kev nyab xeeb hauv peb lub hlis thib peb?
Nyob rau lub sijhawm thib ob thiab peb lub hlis twg, trimethoprim / sulfamethoxazole thiab nitrofurantoin tau txais txiaj ntsig zoothiab los ntawm qee tus suav tias yog thawj kab neeg sawv cev, tshwj tsis yog lub lim tiam dhau los ua ntej xa khoom, thaum lawv tuaj yeem. Ua kom cov kab mob jaundice thiab predispose rau kernicterus [1, 10, 51–55].
Nitrofurantoin puas tuaj yeem ua rau yug tsis haum?
Nitrofurantoin thiab sulfonamides yuav ua rauKev yug me nyuam loj thiab yuav tsum tau siv nrog ceev faj-yog tias tag nrho cov poj niam uas muaj hnub nyoog yug me nyuam. Crider KS, Cleves MA, Reefhuis J, et al. Kev siv tshuaj tua kab mob thaum cev xeeb tub thiab kev pheej hmoo ntawm kev yug me nyuam: National Birth Defects Prevention Study.
