Cov lus xaus: Losartan nce qib bradykinin. Kev txo qis hauv BK-(1-7) / BK-(1-9), Ang II / Ang I, thiab Ang-(1-7) / Ang I ratios qhia tias qhov nce qib bradykinin yog qhov tshwm sim ntawm kev txo cov metabolism los ntawm ACE thiab nruab nrab endopeptidase.
Pob ARBs nce bradykinin?
Kev nce qib ntawm bradykinin ua rau txuas ntxiv prostaglandin E2 synthesis, vasodilation, nce vascular permeability, thiab nce cov kua dej interstitial. Hauv qhov sib piv, cov angiotensin II receptor blockers (ARBs) tsis nce qib bradykinin.
Puas yog losartan inhibit bradykinin?
Kev tswj hwm tus mob losartan tsis cuam tshuam rau bradykinin-vim vasodilatation hauv tib neeg lub hauv pliaj vasculature 33 thiab qhia tias kev hloov pauv hauv qib bradykinin peb tau pom nyob rau hauv txoj kev tshawb fawb tam sim no xav tau kev tswj xyuas ntev.
Dab tsi nce bradykinin?
Ib chav kawm ntawm cov tshuaj hu ua angiotensin converting enzyme inhibitors (ACE inhibitors) nce bradykinin qib los ntawm inhibiting nws degradation, yog li ua rau nws cov ntshav siab txo qis.
Cov tshuaj tiv thaiv ntshav siab twg tseem ua rau qib bradykinin nce?
ARBs nce qib Bradykinin
Losartannce qib bradykinin kwv yees li 2-fold hauv cov ntshav ntawm cov neeg mob ntshav siab (50), zoo ib yam li qhov nce pom nrog ACE inhibition (112, 113).
