Cov kab mob tiv thaiv kab mob thiab cov kab mob txhua tus muaj qhov tsis zoo ntawm cov cell membranes. Qhov no ua rau cov phagocyte thiab cov kab mob raug tshem tawm ntawm ib leeg. Lub opsonin molecule overcomes lub zog repellant ntawm qhov tsis zoo nqi los ntawm kev sib cuam tshuam ntawm opsonin thiab cell nto receptors ntawm lub cev tiv thaiv kab mob.
Dab tsi yog qhov tseem ceeb ntawm cov tshuaj tiv thaiv ua haujlwm ua opsonins rau lub cev tiv thaiv kab mob?
Qee opsonins (suav nrog qee cov proteins ntxiv) muaj hloov zuj zus los khi Pathogen-koom nrog cov qauv molecular, cov molecules tsuas pom nyob rau saum npoo ntawm cov kab mob, ua rau phagocytosis ntawm cov kab mob no, thiab yog li innate tiv thaiv kab mob. Cov tshuaj tiv thaiv kab mob khi rau cov tshuaj tiv thaiv kab mob ntawm cov kab mob, ua kom muaj kev tiv thaiv kab mob.
Lub cev tiv thaiv kab mob twg tuaj yeem ua haujlwm ua opsonin?
Opsonization thiab Membrane Complement Receptors
Cov kuab tshuaj tshwj xeeb, hu ua opsonins, coat particles thiab ua rau cov particles khi avidly rau phagocytes thiab ua rau noj. Qhov kev sib ntxiv (C) system plays lub luag haujlwm tseem ceeb hauv opsonization los ntawm txheej txheej xws li cov kab mob uas ruaj khov C3 thiab C4.
Vim li cas opsonization txhim kho phagocytosis?
Yog li, opsonins ua cov cim lossis cim npe uas tsim cov tshuaj tiv thaiv lossis cov molecule rau kev noj thiab tshem tawm los ntawm phagocytosis. Phagocytosis yog txhim kho los ntawm opsonization vim cov opsonins uas npog lub hom phiajCov txiaj ntsig molecule overriding lub siab nyiam ntawm cov hlwb kom tsis txhob los ze ua ke (Zeta muaj peev xwm).
Puas phagocytosis tshwm sim yam tsis muaj opsonins?
Ntxiv rau opsonic phagocytosis, cov kab mob tuaj yeem nkag mus rau ntawm nws tus kheej ntawm qhov muaj opsonins ntawm lawv qhov chaw. Hom phagocytosis no yog qhov tseem ceeb tshwj xeeb rau kev tshem tawm cov kab mob tshwm sim ntawm cov chaw uas tsis zoo hauv cov tshuaj opsonins xws li lub ntsws.
