DNA los ntawm nws tus kheej yog ib qho tsis muaj zog antigen piv rau macromolecules xws li cov proteins, lipids, thiab glycans. Txawm li cas los xij, qee qhov nucleotide sequences thiab cov qauv txiav txim tuaj yeem ua rau immunogenic. Anti-DNA Abs rau cov kab mob DNA tshwj xeeb muaj nyob rau hauv cov tib neeg noj qab haus huv thiab tsis hnov mob nrog lwm cov kab mob los yog endogenous DNA (61).
Yuav ua li cas thiaj tiv thaiv tau qhov zoo?
Immunogenicity yog lub peev xwm ntawm cov molecule los thov kev tiv thaiv kab mob. Muaj peb yam ntxwv uas ib yam khoom yuav tsum tau ua immunogenic: txawv teb chaws, siab molecular hnyav thiab tshuaj complexity.
DNA puas yog ib qho antigen?
Tseeb tiag, microparticle-sociated DNA sawv cev rau " zoo tagnrho antigen "vim nws qhov loj me [30], qhov chaw raug muab nkag mus rau B hlwb, txheeb ze tiv thaiv degradation, thiab Qhov ntau ntawm cov proteins uas muaj feem cuam tshuam uas tuaj yeem ua haujlwm raws li T cell epitopes lossis ligands rau innate recognition receptors.
Puas yog cov tshuaj tiv thaiv hauv koj cov DNA?
Kev tshuaj ntsuam genetic backup ua rau kev tshawb fawb cov tshuaj tiv thaiv ntau dua thiab tiv thaiv lawv rau yav tom ntej. Lub cev tiv thaiv kab mob tawm tsam cov kab mob ua rau cov kab mob uas siv cov tshuaj tiv thaiv kab mob: Y-zoo li cov proteins uas txhua tus khi rau ib qho txawv teb chaws molecule.
Puas yog nucleic acids Antigenic?
Antigens feem ntau yog cov proteins, peptides, lossispolysaccharides. Lipids thiab nucleic acids tuaj yeem ua ke nrog cov molecules los tsim cov antigens ntau dua, zoo lilipopolysaccharide, uas muaj cov kab mob muaj zog. Ib qho epitope yog lub ntsej muag molecular ntawm ib qho antigen uas tuaj yeem khi los ntawm cov tshuaj tiv thaiv.
