Classical Isosteres yog cov molecules lossis ions nrog cov duab zoo sib xws thiab feem ntau cov khoom siv hluav taws xob. Muaj ntau lub ntsiab txhais. tab sis lo lus feem ntau yog ua haujlwm nyob rau hauv cov ntsiab lus ntawm bioactivity thiab kev tsim tshuaj. Xws li cov tshuaj lom neeg lom neeg uas muaj cov isostere hu ua bioisostere.
Isostere txhais li cas?
: ib qho ntawm ob lossis ntau yam tshuaj (raws li carbon monoxide thiab molecular nitrogen) uas nthuav tawm qhov zoo sib xws ntawm qee yam khoom vim tias muaj tib tus lej ntawm tag nrho lossis valence electrons hauv tib txoj kev npaj thiab uas muaj cov atom sib txawv thiab tsis tas yuav muaj tus lej ntawm cov atoms.
Isosteres nrog piv txwv yog dab tsi?
Isosteres yog atoms, molecules, lossis ions ntawm qhov loj me uas muaj tib tus lej ntawm atoms thiab valence electrons. … Piv txwv 1. Xav txog neon, cov roj zoo kawg nkaus nyob rau qhov kawg ntawm kab thib ob ntawm lub sijhawm teem caij.
Dab tsi yog qhov txawv ntawm classical thiab tsis classical Bioisosteres?
Whereas classical bioisosteres feem ntau txuag ntau ntawm cov qauv zoo ib yam, nonclassical bioisosteres yog ntau ntau dua ntawm cov kev xav tau tshwj xeeb ntawm cov ligand hauv nqe lus nug thiab tuaj yeem hloov tau ib pawg ua haujlwm linear. rau ib lub voj voog moiety, ib pawg alkyl rau qhov nyuaj heteroatom moiety, los yog lwm yam …
Qhov txawv ntawm Isosteres thiab Bioisosteres yog dab tsi?
Friedman (1951): Bioisosteres yog atoms lossis molecules uashaum lub ntsiab lus dav tshaj plaws rau isosteres thiab muaj tib hom kev ua haujlwm lom neeg. Thornber (1979): Cov pab pawg lossis cov molecules uas muaj tshuaj lom neeg thiab lub cev zoo sib xws uas ua rau muaj txiaj ntsig zoo sib xws.
What is Isosteres ? (Chemistry Online Guru)
