Glycosylation pib ntawm endoplasmic reticulum thaum lub sij hawm cov protein synthesis hauv ribosome. … Txawm hais tias glycans tuaj yeem pab ua kom cov protein folding, lawv tshem tawm ntawm cov nqaij npuas kib feem ntau tsis cuam tshuam rau cov protein quav thiab ua haujlwm.
Puas glycosylation tshwm sim ua ntej lossis tom qab cov protein tau muab tais?
Technically, N-glycosylation pib ua ntej cov protein txawm yog txhais, raws li dolicol pyrophosphate oligosaccharide (piv txwv li qab zib "ntoo" - tsis yog lub ntsiab lus, los ntawm txoj kev.) yog synthesized hauv ER (Daim duab 11.4.
glycosylation ua li cas rau cov protein?
Protein glycosylation pab kom folding ntawm cov proteins, ruaj khov thiab hauv cell rau cell adhesion feem ntau xav tau los ntawm cov hlwb ntawm lub cev tiv thaiv kab mob. Cov chaw loj ntawm cov protein glycosylation hauv lub cev yog ER, Golgi lub cev, nucleus thiab cov kua cell.
Puas glycosylation ua cov protein ntau nkag tau?
Ntau qhov kev tshawb fawb tau pom tias glycosylation tuaj yeem ua rau kom muaj kev ruaj ntseg ntawm cov proteins tawm tsamtshuaj lom neeg denaturation.
Yuav ua li cas glycans cuam tshuam rau cov protein folding stability taw qhia kev sib cuam tshuam?
Cov glycans, uas yog bulky hydrophilic polymers, feem ntau ua rausiab solubility ntawm cov proteinthiab ua kom nws ruaj khov tiv thaiv proteolysis. Tsis tas li ntawd, covalent khi ntawm glycans rau cov protein ntau tuaj yeem txhim khoLub thermal thiab kinetic stability ntawm cov proteins.
