2024 Tus sau: Elizabeth Oswald | [email protected]. Kawg hloov kho: 2024-01-13 00:07
Glycosylation pib ntawm endoplasmic reticulum thaum lub sij hawm cov protein synthesis hauv ribosome. … Txawm hais tias glycans tuaj yeem pab ua kom cov protein folding, lawv tshem tawm ntawm cov nqaij npuas kib feem ntau tsis cuam tshuam rau cov protein quav thiab ua haujlwm.
Puas glycosylation tshwm sim ua ntej lossis tom qab cov protein tau muab tais?
Technically, N-glycosylation pib ua ntej cov protein txawm yog txhais, raws li dolicol pyrophosphate oligosaccharide (piv txwv li qab zib "ntoo" - tsis yog lub ntsiab lus, los ntawm txoj kev.) yog synthesized hauv ER (Daim duab 11.4.
glycosylation ua li cas rau cov protein?
Protein glycosylation pab kom folding ntawm cov proteins, ruaj khov thiab hauv cell rau cell adhesion feem ntau xav tau los ntawm cov hlwb ntawm lub cev tiv thaiv kab mob. Cov chaw loj ntawm cov protein glycosylation hauv lub cev yog ER, Golgi lub cev, nucleus thiab cov kua cell.
Puas glycosylation ua cov protein ntau nkag tau?
Ntau qhov kev tshawb fawb tau pom tias glycosylation tuaj yeem ua rau kom muaj kev ruaj ntseg ntawm cov proteins tawm tsamtshuaj lom neeg denaturation.
Yuav ua li cas glycans cuam tshuam rau cov protein folding stability taw qhia kev sib cuam tshuam?
Cov glycans, uas yog bulky hydrophilic polymers, feem ntau ua rausiab solubility ntawm cov proteinthiab ua kom nws ruaj khov tiv thaiv proteolysis. Tsis tas li ntawd, covalent khi ntawm glycans rau cov protein ntau tuaj yeem txhim khoLub thermal thiab kinetic stability ntawm cov proteins.
Pom zoo:
Kev cuam tshuam lossis cuam tshuam?
Affect feem ntau yog cov lus qhia lub ntsiab lus "kom ua rau muaj kev cuam tshuam," xws li " huab cua cuam tshuam nws lub siab." Cov nyhuv feem ntau yog lub ntsiab lus "kev hloov pauv uas tshwm sim thaum ib yam dab tsi ua tiav lossis tshwm sim,"
Puas muaj kev cuam tshuam cuam tshuam qhov ua rau?
Thaum ua rau muaj kev cuam tshuam thiab kev sib raug zoo tuaj yeem tshwm sim nyob rau tib lub sijhawm, kev sib raug zoo tsis txhais hais tias ua rau. Kev ua txhaum yog siv rau cov xwm txheej uas qhov kev txiav txim A ua rau qhov tshwm sim B.
Puas muaj kev cuam tshuam lossis cuam tshuam?
Effected txhais tau hais tias coj los, coj los ua thaum siv los ua lus qhia. … Kev cuam tshuam tuaj yeem siv los ua cov lus qhia dhau los uas txhais tau tias cuam tshuam lossis hloov pauv. Nws kuj tseem tuaj yeem siv los ua ib qho lus hais rau lub npe uas tau cuam tshuam (qhov cuam tshuam lub cev).
Puas tsis cuam tshuam cuam tshuam txog kev ywj pheej?
Cov lus tsis sib xws thiab independent yuav raug siv sib hloov ua lus Askiv, tab sis lawv tsis yog lus piv txwv hauv lej. Independent random variables are uncorrelated, but uncorrelated random variables tsis yog ib txwm ywj siab. Puas yog qhov tsis muaj kev cuam tshuam ib txwm muaj kev ywj pheej?
Puas yog kev cuam tshuam thiab kev cuam tshuam?
Reflection cuam tshuam nrog kev hloov pauv ntawm nthwv dej thaum lawv dhia tawm ntawm qhov thaiv. Kev cuam tshuam ntawm nthwv dej cuam tshuam nrog kev hloov pauv ntawm cov nthwv dej thaum lawv dhau los ntawm ib qho nruab nrab mus rau lwm qhov.
