Ob leeg azathioprine thiab mercaptopurineyog tsim los ntawm ntau tus neeg tsim khoom hauv cov npe sib txawv. Azathioprine tuaj yeem hu ua Imuran, Azafalk, thiab Azapress; thaum mercaptopurine tuaj yeem hu ua Puri-nethol. Mercaptopurine kuj qee zaum hu ua 6-mercaptopurine lossis 6-MP.
Qhov txawv ntawm azathioprine thiab mercaptopurine yog dab tsi?
Azathioprine tau siv rau IBD rau ntau tshaj 30 xyoo. Mercaptopurine yog ib yam tshuaj tshiab thiab zoo li yuav raug tshuaj tsawg dua hauv UK. Ntau qhov kev tshawb fawb tau pom tias cov tshuaj no tuaj yeem pab txo qis cov tsos mob thiab tswj kev tso tawm nyob rau ntawm rau rau ntawm 10 tus neegnrog UC thiab xya tawm ntawm 10 tus neeg uas muaj Crohn.
YPuas azathioprine yog mercaptopurine?
Zoo li tag nrho cov thiopurines, mercaptopurine yog a purine analogue, thiab ua raws li cov tshuaj tiv thaiv kab mob los ntawm kev cuam tshuam nrog nucleic acid synthesis thiab inhibiting purine metabolism.
YPuas azathioprine 6 yog mercaptopurine?
Metabolism ntawm 6-mercaptopurine (6-MP) thiab azathioprine (AZA) yog qhov nyuaj. Azathioprine yog ib qho tshuaj uas yog tsis-enzymatically hloov pauv rau 6-MP.
Kev sib raug zoo ntawm azathioprine thiab 6-mercaptopurine ua tshuaj yog dab tsi?
Thiopurines (piv txwv li, azathioprine [AZA] thiab mercaptopurine, tseem hu ua 6-mercaptopurine, [6-MP]) siv cov tshuaj glucocorticoid-sparing rau cov neeg mob uas muaj kab mob plab hnyuv (IBD) uastsis tuaj yeem tswj xyuas kev zam txim thaum glucocorticoids tapered thiab thim.
