Tamm-Horsfall (TH) glycoprotein yog ib cov protein tseem ceeb ntawm cov zis ib txwmthiab yog thawj feem ntawm waxy nephron casts. Tamm-Horsfall protein yog los ntawm lub raum keeb kwm thiab tau nyob rau hauv lub tuab ascending limb ntawm lub voj ntawm Henle thiab nyob rau hauv lub distal convoluted tubule.
Tamm-Horsfall protein ua nyob qhov twg?
Tamm–Horsfall protein (THP), lossis uromodulin (UMOD), yog 80–90-kDa phosphatidylinositol-anchored glycoprotein uas tsim tshwj xeeb los ntawm lub raum tubular hlwb hauv cov ceg tuab ntawm lub voj voog. ntawm Henle.
Tus kab mob raum uromodulin yog dab tsi?
Uromodulin-associated raum kab mob yog ib yam mob uas cuam tshuam rau lub raum. Cov tsos mob thiab cov tsos mob ntawm tus mob no txawv, txawm tias ntawm cov tswv cuab ntawm tib tsev neeg. Ntau tus neeg uas muaj uromodulin-mob raum kab mob tsim cov ntshav siab ntawm cov khoom pov tseg hu ua uric acid.
Yuav ua li cas yog uromodulin?
Kev tshawb fawb feem ntau siv Umod-knockout nas tau pom tias uromodulin muaj lub luag haujlwm hauv tswj ntshav siab, zis concentration, ua kom lub cev tsis muaj zog thiab tiv thaiv lub raum pob zeb tsim thiab kab mob urinary (UTIs).
Qhov twg ntawm lub raum yog uromodulin tsim?
Nws tsis yog muab los ntawm cov ntshav ntshav tab sis yog tsim los ntawm lub tuab nce siab ntawm lub voj ntawm Henle ntawm lub raum mammalian.
