Sulfonamides thiab trimethoprim tsom rau folic acid biochemical txoj hauv kev ntawm cov kab mob. Cov tshuaj tua kab mob no yog hu ua folic acid pathway inhibitors. Sulfonamides cuam tshuam nrog kev tsim ntawm folic acid, ib qho tseem ceeb precursor rau nucleic acid synthesis.
Yuav ua li cas cov tshuaj tua kab mob hauv qab no yog folate synthesis inhibitor?
5.2 Trimethoprim . TMP yog cov tshuaj tua kab mob hluavtaws uas khi nrog cov enzyme dihydrofolate reductase (DHFR) inhibiting folic acid synthesis pathway (Brogden li al., 1982). Nws yog dav siv nyob rau hauv kev kho mob ntawm urinary kab mob thiab Pneumocystis jiroveci pneumonia.
Yuav tshuaj pab pawg twg inhibits folic acid synthesis?
Sulfonamides, chav kawm ntawm cov tshuaj tua kab mob uas ua haujlwm los ntawm inhibiting folate biosynthesis.
YFolate synthesis yog dab tsi?
Folic acid yog ib qho khoom noj tseem ceeb tsim nyog rau cov protein thiab nucleic acid synthesis(DNA thiab RNA). Folic acid yog tsim los ntawm cov kab mob los ntawm substrate, para-amino-benzoic acid (PABA), thiab tag nrho cov hlwb xav tau folic acid rau kev loj hlob. Folic acid (raws li vitamin nyob rau hauv cov zaub mov) diffuses los yog raug thauj mus rau hauv mammalian hlwb.
Cov tshuaj twg raug cais ua cov tshuaj folate antagonists?
Ntau cov tshuaj xws li aminopterin, methotrexate (amethopterin), pyrimethamine, trimethoprim thiab triamterene ua raws li cov tshuaj tiv thaiv folate thiab tsim cov folate.deficiency los ntawm inhibiting no enzyme.
