Adenine di-Phosphate (ADP) yog ib qho tseem ceeb ntawm lub cev agonist uas ua si lub luag haujlwm tseem ceeb hauv cov hemostasis thiab thrombosis. … Tsis tas li ntawd, P2Y12 receptor kuj tseem ceeb rau kev muaj peev xwm ntawm platelet activation mediated los ntawm lwm cov physiological agonists xws li collagen, von Willebrand thiab thromboxane A2.
ADP yog dab tsi hauv ntshav txhaws?
Adenosine diphosphate (ADP) tso tawm los ntawm platelet ntom granules ua rau kev khi ntawm fibrinogen rau platelet receptor GPIIb-IIIa, uas ua rau tsim cov fibrinogen txuas hniav uas txuas platelets mus rau hauv ib qho xoob aggregate.
Dab tsi yog qhov ua haujlwm ntawm ADP hauv platelets?
ADP tsis yog ua rau thawj qhov sib sau ua ke ntawm plateletstab sis kuj yog lub luag haujlwm rau kev sib sau ua ke thib ob uas tau tshwm sim los ntawm ADP thiab lwm cov agonists. ADP kuj ua rau cov platelet zoo hloov, tso tawm los ntawm cov granules cia, influx thiab intracellular mobilization ntawm Ca2+, thiab inhibition ntawm stimulated adenylyl cyclase kev ua.
Vim li cas ADP thiab thromboxane tseem ceeb rau kev tsim cov platelet ntsaws?
Platelet Activation
Qhov ntxiv ADP thiab VWF yog qhov tseem ceeb tshwj xeeb vim nws ua rau cov platelets nyob ze ua raws thiab qhib, nrog rau tso tawm ntau ADP, VWF, thiab lwm yam tshuaj. … Thromboxane yog ib qho arachidonic acid derivative (zoo ib yam li prostaglandins) uas ua rau lwm cov platelets thiabtswj vasoconstriction.
ADP ua rau platelet aggregation li cas?
Ua los ntawm cov cell nto receptors , ADP ua kom cov platelets ua rau cov duab hloov pauv, sib sau ua ke, thromboxane A 2 ntau lawm, thiab tso tawm cov ntsiab lus granule.
