Cov molecules ntawm neuromuscular thaiv cov neeg ua haujlwm yog hydrophilic thiab ionized, thiab yog li tsis feem ntau hla cov rog rogxws li cov ntshav-hlwb thaiv kom nkag mus rau hauv nruab nrab paj hlwb lossis cerebrospinal kua. Yog li ntawd lawv zoo li tsis zoo li yuav cuam tshuam ncaj qha rau cov xwm txheej raug tshuaj loog.
Puas atracurium hla cov ntshav-hlwb barrier?
Cov metabolite tseem ceeb ntawm atracurium, laudanosine, tuaj yeem hla cov ntshav – hlwb teeb meem (CSF / plasma ratios ntawm 0.3–0.6 muaj nyob rau hauv dev) (25) thiab tsim strychnine -zoo li lub paj hlwb stimulation, uas nyob rau hauv siab plasma concentrations (nyob ib ncig ntawm 17 ng / ml) ua rau convulsions nyob rau hauv dev (25–27).
Puas neuromuscular blockers hla cov ntshav-hlwb barrier?
Keeb Kwm: Txawm hais tias cov tshuaj tiv thaiv neuromuscular tsis hla cov ntshav-hlwb teeb meem, lawv tuaj yeem nkag mus rau hauv nruab nrab cov hlab ntsha hauv cov xwm txheej tshwj xeeb thiab thaum kawg ua rau muaj qhov tshwm sim neurotoxic.
Puas pancuronium hla cov ntshav-hlwb barrier?
KEY WORDS Lub hlwb: ntshav-hlwb barrier. Cerebrospinal kua: tshuaj hloov tshuaj Neuromuscular relaxants: pancuronium. Nws tau lees paub feem ntau tias quaternary tebchaw nrog lub chaw molecular nqa tus nqi zoo tsis hla cov ntshav-hlwb thaiv(BBB) hauv cov ntsiab lus zoo txaus los cuam tshuam rau lub hlwb.
YYog succinylcholine ib qho neuromuscularthaiv tus neeg sawv cev?
Lawv sib tw nrog acetylcholine thiab cuam tshuam nrog kev sib kis ntawm cov hlab ntsha impulses uas ua rau cov leeg pob txha so. Raws li lawv cov txheej txheem ntawm kev ua, cov tshuaj tiv thaiv neuromuscular raug cais raws li depolarizing lossis nondepolarizing. Succinylcholine yog tus neeg ua haujlwm luv luv-depolarizing.
