Nociceptive primary afferents tso glutamate, activating postsynaptic glutamate receptors on spinal cord dorsal horn neurons. Glutamate receptors, ob qho tib si ionotropic thiab metabotropic, kuj tau nthuav tawm ntawm presynaptic terminals, qhov chaw uas lawv tswj cov neurotransmitter tso tawm.
Cov qe dab tsi tso glutamate?
Txawm hais tias glutamate muaj nyob rau hauv tag nrho neurons, tsuas yog ob peb tus glutamatergic, tso glutamate ua lawv cov neurotransmitter. Neuroactive glutamate yog khaws cia hauv synaptic vesicles hauv presynaptic axon terminals (4). Glutamate tau muab tso rau hauv cov hlwv los ntawm glutamate transporter nyob rau hauv lub vesicular membrane.
Puas glutamate activate nociceptors?
Pov thawj los ntawm ob peb lub xyoo dhau los qhia tias excitatory amino acid glutamate plays lub luag haujlwm tseem ceeb hauv kev ua haujlwm tsis txaus ntseeg. Glutamate thiab glutamate receptors nyob rau hauv cov cheeb tsam ntawm lub hlwb, qaum qaum thiab periphery uas muaj feem xyuam rau qhov mob thiab kis tau tus mob.
Glutamate tso tawm li cas?
Nquag, raws li glutamate raug tso tawm los ntawm "tus xa xov-xa" paj hlwb, nws khi rau NMDA thiab tsis yog NMDA receptors ntawm cov hlab ntsha tau txais. Vim tias cov tsis-NMDA receptors tsis raug thaiv, kev khi ntawm glutamate ib leeg qhib cov receptors thiab tso cai rau cov ions zoo kom ntws mus rau hauv lub cell.
Pob nociceptors tso cov neurotransmitters?
Tsis paubstimuli qhib TRP raws nyob rau ntawm cov hlab ntsha xaus, uas ua rau thawj-order neurons rau depolarize thiab tua hluav taws muaj peev xwm. Kev ua tej zaum yuav txiav txim siab siv zog. Lub delta fibers tso glutamate mus rau qhov thib ob-order neurons, thaum C fibers tso tawm neuropeptide neurotransmitters.
