Tus txheej txheem ntawm polyadenylation pib raws li kev hloov pauv ntawm cov noob txiav. … Txawm li cas los xij, hauv ob peb hom ntawm tes, mRNAs nrog luv poly(A) tails yog khaws cia rau tom qab ua kom rov qab los ntawm polyadenylation hauv cytosol. Hauv qhov sib piv, thaum polyadenylation tshwm sim hauv cov kab mob, nws txhawb RNA degradation.
poly A tail ntxiv li cas?
Tam sim ntawd tom qab cov noob hauv eukaryotic cell tau sau tseg, RNA molecule tshiab tau dhau los ua ntau qhov kev hloov kho hu ua RNA ua. Cov kev hloov kho no hloov ob qhov kawg ntawm thawj RNA cov ntawv sau los tsim kom muaj mRNA molecule paub tab. Kev ua ntawm 3' kawg ntxiv poly-A tail rau RNA molecule.
Vim li cas polyadenylation tshwm sim ua ntej splicing?
Rau cov ntawv sau luv luv, RNA splicing feem ntau ua raws li kev sib cais thiab polyadenylation ntawm 3′ kawg ntawm thawj cov ntawv sau tseg. Tab sis rau ntev transcription units uas muaj ntau exons, splicing ntawm exons nyob rau hauv nascent RNA feem ntau pib ua ntej transcription ntawm cov noob tiav.
Vim li cas 3 polyadenylation tshwm sim?
Polyadenylation ntawm 3′ kawg tshwm sim ua ntej mRNA tawm ntawm lub nucleus. Qhov no polyadenylate tus Tsov tus tw, nyob ib ncig ntawm 100-200 nucleotides ntev, tiv thaiv mRNA los ntawm degradatory kev txiav txim ntawm phosphatase thiab nucleases.
YPuas polyadenylation tshwm sim hauv cov nucleus?
Lub polyadenylation ntawm mRNAs feem ntau xav tias yog txheej txheem uas tshwm sim hauvnucleus, thiab qhov tseeb no yog cellular compartment nyob rau hauv uas pre-mRNA ua thiab polyadenylation tshwm sim. Txawm li cas los xij, mRNA polyadenylation tsis txwv rau lub nucleus.
