Physostigmine inhibits acetylcholinesterase, lub enzyme lub luag haujlwm rau kev rhuav tshem ntawm kev siv acetylcholine. Los ntawm kev cuam tshuam nrog cov metabolism ntawm acetylcholine, physostigmine indirectly nkoos ob leeg nicotinic thiab muscarinic receptors vim qhov tshwm sim nce nyob rau hauv muaj acetylcholine ntawm lub synapse.
tshuaj physostigmine ua dab tsi?
Physostigmine yog ib qho acetylcholinesterase inhibitor uas tuaj yeem nkag mus thiab txhawb nqa lub hauv paus paj hlwb. Physostigmine yog siv los kho tus mob glaucoma thiab qeeb plab zom mov.
hom kev ua ntawm physostigmine yog dab tsi?
Physostigmine ua by cuam tshuam nrog cov metabolism ntawm acetylcholine. Nws yog ib qho reversible inhibitor ntawm acetylcholinesterase, lub enzyme lub luag hauj lwm rau kev tawg ntawm acetylcholine nyob rau hauv lub synaptic cleft ntawm lub neuromuscular hlws ris. Nws indirectly nkoos nicotinic thiab muscarinic acetylcholine receptors.
Puas yog physostigmine yog agonist lossis antagonist?
Tus acetylcholine esterase inhibitor (-)-physostigmine tau pom tias ua raws li agonist ntawm nicotinic acetylcholine receptors los ntawm cov leeg thiab hlwb, los ntawm kev khi rau qhov chaw ntawm alpha-polypeptide uas yog qhov txawv ntawm cov khoom siv rau lub ntuj transmitter acetylcholine (Schröder li al., 1994).
Qhov cuam tshuam ntawm physostigmine yog dab tsi?
Cov teebmeem tshwm sim feem ntau los ntawm physostigmine yog cov khoom siv peripheralcholinergic manifestations (xws li, ntuav, raws plab, mob plab, diaphoresis). Physostigmine kuj tseem tuaj yeem ua rau qaug dab peg, ib qho teeb meem nquag tshaj tawm thaum muab rau cov tib neeg uas muaj tricyclic antidepressant lom.
